Miniaturisation pour la Synthèse, l’Analyse et la Protéomique (MSAP) UAR 3290

Flow chemistry

FT-ICR 2D diagram

Flow chemistry in microfluidic reactors is a field in high development. Microfluidic conditions allow driving and study reactions in tubular microreactors of some hundreds of µL. The interest for microfluidic condition is motivated by various advantages. A reduction of scales goes hand in hand with i) the increase of the surface/volume ratio, a million superior times compared to the scale of conventional laboratory glassware, ii) a big speed up of the operations and possible automatization of the process

Four research projects will be developed:

  1. the first will concern the study of very reactive and unstable species (arynes, nitrenes, free radical, carbocations, …) at very short times and their use as organic reactants for a large set of reactions with a particular focus on physical organic chemistry for the determination of their lifetimes and (stereo)selectivity control ;
  2. the second will concern new activation methodologies: we will extend flow photochemistry to the UVB&C range by developing high power LED system with wavelength down to 300 nm, since photochemistry involve very often photoredox mechanisms a natural connection from photochemistry to electrochemistry in flow we will develop along the next few years
  3. our knowledge acquired in the field of nanoparticle and polymer synthesis in flow permits to envisage new developments for the synthesis of poly-hetero-metallic particles or organic-inorganic nanoparticles (e.g. core shell and encapsulated structures): the reactivity modulation of their surface by irradiation of their plasmon band resonance or by photoredox transfer open new perspectives for various fields of research
  4. the development of nanofluidic reactor in order to approach the molecular scale is a fundamental and technical challenge – preliminary results from our laboratory gives the basics for the design of a functional reactor.